BoNT with its extreme specificity for neuronal cells is now being targeted for designing drug delivery vehicle in combination with nanoparticles and liposomes. Proof of concept research has already been carried out at the Center, and currently proposals are being prepared to obtain funding to develop drug delivery vehicles against several neuronal and brain diseases, including amyotrophic lateral sclerosis disease.
Neurogenesis is a complex process and require multipronged approach for effective therapeutic intervention. There are two major aspects in the recovery of injured or degenerated neurons; a) axonal regeneration, and b) synaptic activities. Our project will result in a novel non-viral based target-selective drug delivery system (selective to neuronal cells) to delivery an enzyme or protein chimeras that will promote axonal growth and improve synaptic plasticity in neurons.